In 1935, the cartoon character Betty Boop starred in a short film called: "No! No! A Thousand Times No!"
That title is the best short answer to the question of whether you should microdose while taking antidepressants.
But the real answer is more nuanced — and more important.
Microdosing and antidepressants go together like peanut butter and mayonnaise.
SSRIs and SNRIs — the most common antidepressants — work by blocking serotonin reuptake. Psilocybin works primarily by binding to serotonin receptors. When you're already flooding those receptors with an SSRI, the psilocybin has nowhere to land.
The result: the microdosing doesn't work as well, or doesn't work at all. You're paying for a supplement that's being blocked by the medication you're already taking.
We do have some customers who've figured out how to make it work — they time their doses carefully, they've worked with their doctors to adjust their prescriptions. They're like Microdosing All-Stars. But they're the exception, not the rule.
Most people who come to microdosing are already unhappy with their antidepressants. They've gained weight. They've lost their appetite for intimacy. They feel blah — not depressed exactly, but not themselves either.
When they start microdosing, something shifts. And for many of them, that shift gives them the strength to do something they never thought they'd be able to do: stop taking the antidepressants.
Debra's Story
When Debra started microdosing, she did something she never thought she'd have the strength to do: she threw out her antidepressants.
And a funny thing happened. She also stopped drinking compulsively. She stopped feeling angry at everyone. She used to just look forward to going to sleep — sometimes going to bed at 7pm because she didn't want to do anything.
After she started microdosing, she said she just felt alive again.
Her grown son told her: "I don't know what happened when you started taking these mushrooms, but I feel like I have my mom back."
What Our Customers Report
We're not doctors and we can't tell you what to do with your prescriptions. But we can tell you what we've seen from thousands of customers: the ones who get the best results from microdosing are the ones who aren't taking SSRIs at the same time.
If you're on antidepressants and want to try microdosing, talk to your doctor. Many doctors are now familiar with psilocybin research and can help you think through a transition plan.
The goal isn't to be on something forever. The goal is to feel like yourself again.
More Voices
"This is the real deal. I took antidepressants for 30 years and they never helped me like this product does."
— Leanne Ortiz
"Depression and anxiety are damn near non-existent. I feel like a new person."
— Joseph Cuellar
The Underground Health Report is an independent publication. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Always consult your physician before changing or stopping any medication.